Chiral column chromatography


Chiral column chromatography is a variant of column chromatography that is employed for the separation of optical isomers. The stationary phase contains a single enantiomer of a chiral compound.
The chiral stationary phase can be prepared by attaching a chiral compound to the surface of an achiral support such as silica gel. Common chiral stationary phases are based on oligosaccharides such as cellulose or cyclodextrin.
The principle can be also applied to the fabrication of monolithic HPLC columns or gas chromatography columns.