Born in Ioannina, Charisis began playing football with PAS Giannina. On 19 January 2014, he made his professional debut for PAS Giannina in a match against Kalloni.
Charisis will wear the jersey of PAOK from summer 2015 along with Nikos Korovesis. The two aces will be two of several acquisitions of PAOK in summer season. The players were about to sign to PAOK with the consent of the administration of PAS Giannina. According to absolutely reliable information is an agreement between the two major shareholders. Both are agreed on all the basics, with PAOK, but however nothing is announced yet. On 25 June 2015, PAOK announced the acquisition of the player for four years for an undisclosed fee. On 25 October 2015, he made his Superleague debut with the club in a 3–1 home win against rivals Panathinaikos. On 10 January 2016, he scored his first goal against his hometown team PAS Giannina in a 3–0 home win game.
On 26 June 2017, the details of Charisis borrowing to Belgian club Sint-Truiden are of interest as they prove that the deal is identical to what was done for Stelios Kitsiou. The borrowing comes with a €1.5 million purchase option and 20% resale. On 2 December 2017, he scored his first goal with the club in an away 1–1 draw against Royal Excel Mouscron. On 1 January 2018, he suffered a tear in the abductor muscle, following by a training deficit due to technical turf, that kept him out of the squad for almost 3 months.
Loan to Kortrijk
On 23 August 2018, Charisis will continue his career in Belgium as a loan from PAOK. The Belgian team announced the acquisition of the 24-year middlefielder, while retaining a purchase option for the summer of 2019.
Atromitos
On 24 June 2019, Charisis penned a two-year deal with the Peristeri-based club. Charisis, a versatile midfielder, shared his emotions from the move: “I am very happy to join the Atromitos family. This is a new challenge for me and I will do my best to prove that I can offer a lot to this team. I will help the team achieve its goals in both Greece and Europe. Tomorrow, I am looking forward to training with the team for the first time in front of our fans.” Charisis has moved to Atromitos as a free agent after leaving PAOK.
