It is not known when Cen Changqian was born. His father was Cen Wenshu, an older brother of Cen Wenben, who served as chancellor during the reign of Emperor Taizong of Tang. Cen Wenshu died early, so Cen Wenben raised Cen Changqian as his own son.
During Emperor Gaozong's reign
As of 682, late in the reign of Emperor Gaozong, Cen Changqian was serving as the deputy minister of defense, when he was given the designation Tong Zhongshu Menxia Pingzhangshi, making him a chancellor de facto.
Emperor Gaozong died in 683, and while his son Li Zhe succeeded him, his very powerful wife Empress Wu took over all power as regent and empress dowager. In spring 684, when Emperor Zhongzong displayed signs of independence, Empress Dowager Wu by official order deposed him and replaced him with his younger brotherLi Dan the Prince of Yu. However, Empress Dowager Wu held onto power even more firmly thereafter. in 686, Cen, who was by that point minister of defense, was made Neishi -- the head of the legislative bureau of government and a post considered one for a chancellor; he also continued to serve as minister of defense. In 688, when Emperor Gaozong's brother Li Zhen, the Prince of Yue, and Li Zhen's son Li Chong, the Prince of Langye, suspecting that Empress Dowager Wu was set on seizing the throne herself, rose in rebellion, Cen was one of the generals that Empress Dowager Wu sent against Li Zhen. Li Zhen was quickly defeated, and it is not clear whether Cen participated in Li Zhen's defeat. In 690, Cen was made Wenchang Youxiang, one of the heads of the executive bureau of government, and also carried the designation Tong Fengge Luantai Sanpin, signifying that he was still a chancellor.
During Wu Zetian's reign
Later in 690, Empress Dowager Wu took the throne herself and took the title of "emperor," demoting Emperor Ruizong to be crown prince, but with the unusual title of Huang Si rather than the usual title of Huang Taizi, and she changed the name of the state from Tang to Zhou. She encouraged people to submit signs of fortune and of Zhou's rise, and it was said that Cen Changqian, apprehensive of his situation, submitted a proposal to have Crown Prince Dan's surname changed from Li to Wu, which Wu Zetian accepted. To reward Cen, she created him the Duke of Deng, and further bestowed on him the surname of Wu as well as the honorific titleTejin. However, Cen would soon offend Wu Zetian and her Wu clan members. There had been a movement started by the official Zhang Jiafu and the commoner Wang Qingzhi to have Wu Zetian's nephew Wu Chengsi made crown prince—under the theory that given that Wu Zetian was now emperor, she should be succeeded by a member of the Wu clan rather than her husband's Li clan. They circulated a petition among officials, and Cen refused to sign—and further suggested to Wu Zetian that, as Wu Dan was already crown prince, this proposal should be firmly rejected and that the group of people that Zhang and Wang had gathered before the palace to petition Wu Zetian should be disbanded. He was supported in this by fellow chancellor Ge Fuyuan. Cen and Ge's actions offended both Wu Zetian and her Wu clan members. At that time Buddhist monks from He Prefecture submitted a sutra, the Dayun Sutra, which purportedly foretold Wu Zetian's rise to power. Wu Zetian issued an edict that this find be commemorated by the construction of the impressive Dayun Temple. Cen opposed this as well, further drawing her displeasure. To remove Cen from the capital Luoyang, in late 690, she ordered him lead an army against the Tufan, but even before his army could reach the front, she recalled him to Luoyang and imprisoned him. One of Wu Zetian's favored secret police officials, Lai Junchen, then tortured Cen's son who was serving as Magistrate of Lingyuan and obtained a confession implicating Ge and fellow chancellor Ouyang Tong, as well as a large group of other officials. In winter 691, Cen Changqian, Ge, and Ouyang were all executed. Cen Changqian's five sons were forced to commit suicide, and his ancestral tombs were destroyed. Dozens upon dozens of officials and their relatives were executed, exiled, or fled to Southern China during the reign of Wu Zetian. After Emperor Ruizong was eventually restored to the throne in 710, he restored Cen's titles and reburied him with honor. His nephew Cen Xi later also served as a chancellor during Emperor Ruizong's and Emperor Xuanzong's reigns.