Between 2002 and 2009, Wikström was a member of the Swedish Parliament for the Liberal People's Party. She was Deputy Chairman of the Committee on Cultural Affairs and substitute member of the Committee on Foreign Affairs. Wikström has been very engaged in questions relating to freedom of expression, in Sweden as well as in other countries. In 2009 Wikström ran for the elections to the European Parliament on June 7. She was the third name on the Swedish Liberal People's Party list and was elected to represent the party in the European Parliament. Hence, she left her post in the Swedish Parliament in July 2009.
Member of the European Parliament, 2009–2019
Wikström is a Member of the European Parliament since 2009. She is a member of the European Parliament groupAlliance of Liberals and Democrats for Europe. In the European Parliament, Wikström was from 2009 to 2014 a full member of the Committee on Civil Liberties, Justice and Home Affairs and the Committee on Legal Affairs, where she also is the coordinator of the ALDE group. In addition to her committee assignments, she was a member of the European Parliament’s Advisory Committee on the Conduct of Members from 2012 until 2014. In spring 2013, Wikström was appointed to represent the ALDE group in the delegation that negotiated a new agreement between the European Parliament and other institutions on how the European Parliament should have access to classified documents related to the common policy of security and foreign affairs. She was substitute member of the Delegation to the EU-Moldova Parliamentary Cooperation Committee, the Delegation to the ACP-EU Joint Parliamentary Assembly and the Delegation to the Euronest Parliamentary Assembly. In the 2014-2019 legislature, Wikström was a full member of the Committee of Civil Liberties, Justice and Home Affairs and was formerly a substitute member of the Committee of Legal Affairs. On 7 July 2014, she was elected a Chairwoman of the Committee for Petitions. From 2017, Wikström chaired the Conference of Committee Chairs. She was also a member of the European Parliament Intergroup on the Western Sahara and the European Parliament Intergroup on LGBT Rights. and vice-chair of the Intergroup for Disabled People. On 29 March 2019 the Liberal Party decided on their list of candidates for the 2019 EU election, on which Wikström would not appear.
In 2019, Wikström was one of five candidates for the post of European Ombudsman. In the final ballot in the European Parliament on 18 December 2019, she came in fourth, with only 38 votes.
Wikström has written and published two books. In 2004 she published När livet går sönder, a book about crisis management. Her second book I tillitens tecken was published in 2006. She has also held various positions in national and regional boards, such as the Swedish UNESCO Board, the Police County Board and Liberal Women group in Uppsala County. Since 2001 she is the owner and executive Director of Wikström Consulting LTD. Wikström is of Tornedalian descent. Tiina Laitila Kälvemark