According to The Observer, during the 1980s Caplin worked for the telemarketing company Programmes Ltd, and became involved in the related Exegesis alternative therapy programme. Later Caplin set up a series of health and well-being companies. Caplin has written a number of health and well-being books, and appeared in several television programmes, including presenting her own Channel 4 programme The Carole Caplin Treatment.
Cheriegate
In 2002, Caplin hit the newspaper headlines in the scandal referred to as "Cheriegate" because of her involvement with Peter Foster, an Australian with criminal convictions, who assisted the Prime Minister's wife, Cherie Blair, in the purchase of two flats in Bristol. Cherie Blair tried to distance herself from Foster and briefed the press office at 10 Downing Street to make a public statement claiming that Foster was not involved with the deal. She was caught out when Foster provided evidence that she had lied. She then made a public apology, tearfully reading a prepared statement blaming her "misfortune" on the pressures of running a family and being a mother. She again tried to distance herself from Foster, but it was later revealed that she and Tony Blair had agreed to be godparents to the yet-to-be born child of Carole Caplin.
''Daily Mail'' libel case
In 2010 Caplin started libel proceedings against the Daily Mail for a newspaper article that suggested that Caplin might have been considering selling the story of her time with the Blairs and to "blow the lid on Tony and Cherie Blair’s sex secrets". It was announced on 1 November 2011 that Caplin has accepted "substantial" damages from the newspaper for the false claims the Mail had made.
''News of the World'' phone-hacking target
On 1 November 2011 Caplin announced that the Metropolitan Police had told her that her mobile phone was probably hacked on the instructions of the News of the World. Caplin's spokesman stated "Dating from 2002, Ms Caplin's is one of the earliest cases so far discovered and the police investigation has yet to uncover all the available evidence. Once she is able to establish the extent of this invasion of her privacy, Ms Caplin will decide what further action to take." Alastair Campbell, Tony Blair's former communications director, told the Leveson inquiry that it was "at least possible" that press stories about Cherie Blair had been obtained by hacking Caplin's phone, and he had apologised to Caplin that he had earlier accused her of tipping off newspapers.