Talbot grew up in Caledonia, Ontario, and started playing with the Caledonia Thunder MHA programs before making the leap to the Hamilton Jr. Bulldogs of the South Central AAA League in Minor Bantam. He played three seasons of AAA hockey, was undrafted in the 2003 OHL Priority Selection and returned to the Jr. Bulldogs, where he played a season of Major Midget. After a solid Major Midget season, Talbot made the Hamilton Red Wings of the Ontario Junior Hockey League for the 2004–05 season. Talbot played college hockey at the University of Alabama in Huntsville. In the 2009–10 season, he was named to the All-College Hockey America Second Team and was named Most Valuable Player in the CHA Tournament, while leading the Chargers to a berth in the NCAA Tournament.
Professional
New York Rangers
On March 30, 2010, the NHL's New York Rangers signed Talbot as a free agent. He was promoted to the Rangers on February 28, 2011, after playing the majority of the 2010–11 season with the Connecticut Whale of the American Hockey League and was returned to the Whale on March 3, 2011. Talbot played the 2011–12 season with Connecticut, but after Connecticut was eliminated from the AHL playoffs, Talbot was added to the Rangers' Stanley Cup playoff roster. After the 2012–13 Whale season, he was again added to the Rangers' playoff roster. Talbot was again called up to the Rangers on October 15, 2013, after Martin Biron was demoted to the AHL, finding himself a place in the NHL for the first time as the backup to starter Henrik Lundqvist. Talbot made his on-ice NHL debut on October 24 in a 2–1 loss to the Philadelphia Flyers. His first NHL win came in his next game, against the Detroit Red Wings, on October 26, 2013, and he earned his first NHL shutout against the Montreal Canadiens on November 16, 2013. In the 2014 playoffs, Talbot twice entered to relieve Lundqvist en route to the Rangers' Eastern Conference title before ultimately falling to the Los Angeles Kings in the Finals. For the 2014–15 season, Talbot began the year as the Rangers' backup goaltender, and in his first eight games played, he recorded three shutouts, matching his total from the entire previous season. On February 3, 2015, Talbot became New York's temporary starting goaltender after Henrik Lundqvist suffered a ruptured blood vessel in his neck. Talbot started 24 of the Rangers' next 26 games until March 27, when Lundqvist returned to the line-up. During Lundqvist's absence, Talbot performed better in net and went 17–4–3. In fact, Talbot ended the season with a lower GAA, and a higher save percentage than Lundqvist. For his remarkable efforts towards New York's Presidents' Trophy-winning season, he received the Steve McDonald Extra Effort Award on April 6.
Edmonton Oilers
On June 27, 2015, Talbot was traded by the Rangers to the Edmonton Oilers in exchange for three draft picks in the 2015 NHL Entry Draft. Talbot competed for Edmonton's #1 goaltender spot with Anders Nilsson during his first season with the Oilers. On January 17, 2016, the Oilers signed Talbot to a three-year, $12 million contract extension. Nilsson was eventually traded to the St. Louis Blues, leaving Cam Talbot as Edmonton's starting goaltender. On April 6, 2017, Talbot set an Oilers record for most wins in a season passing Grant Fuhr, who had 40 wins, by earning 41 wins. Talbot finished the season by leading the NHL in games played and time on ice by a goaltender, as well as tied for first in wins with 42. The Oilers finished that season second in the Pacific Division, with 103 points. Talbot helped his team reach Game 7 of the Western Semifinals, losing to the Anaheim Ducks in what was the first playoff appearance by the Oilers in ten years. Talbot finished the playoffs with a 2.88 GAA,.924 save percentage and two shutouts. On October 4, 2017, Talbot recorded a 27-save shutout in the 2017–18 season-opener against the Calgary Flames. Talbot and the Oilers would not be able to replicate the previous season's success, and missed the playoffs. Talbot finished the season with a 31–31–3 record with a goals-against-average of 3.02.
Philadelphia Flyers
During the 2018–19 season, on February 15, 2019, Talbot was traded by the Oilers to the Philadelphia Flyers in exchange for Anthony Stolarz.
Calgary Flames
On July 1, 2019, having left the Flyers as a free agent, Talbot was signed to a one-year, $2.75 million deal with the Calgary Flames.
Personal life
Talbot married his wife Kelly in 2012, and the two had twins in October 2016. Talbot is a fan of Ghostbusters, and is known to incorporate Ghostbusters artwork into his mask designs.
International play
Talbot attended the 2016 IIHF World Championship as the starting goaltender for Team Canada. He led the team to its second straight gold medal at the tournament and tied a tournament record for shutouts with 4.
