The Ramón Emeterio Betances Street starts at the Barcelona Gate of the University of Puerto Rico at Mayagüez where a flagpole is placed with the Puerto Rican flag aside a José De Diego iron bust. It states that the Recinto Universitario de Mayagüez was founded as Colegio de Agricultura y Artes Mecánicas by José De Diego on September 23, 1911. Just facing the UPRM's Barcelona Gate is a junction where merges the Avenida Alfonso Valdés Cobián and Pedro Albizu Campos Avenue aside with the Parque de los Próceres. In this point the road runs over a 6-lane bridge over the Yagüez River going southbound to Barcelona Sector, where some fast foods, a gas station, shops and pubs like the legendary El Garabato are located. The Radiocentro Building is located next, marking the entrance to Calle Bosque. Going south way, the Ramón Emeterio Betances Street passes the Millonarios Street which marks the entrance to former Hacienda Guenard and the beginning of the historical downtown zone. Here is placed the Hospital San Antonio, founded by Dr. Ramón Emeterio Betances in 1865 with citizen fund-raising. Near is located the Hospital Perea and El Cacique lounge. At intersection with José De Diego Street are located two private colleges: Colegio Presbiteriano Pablo Casasús and the catholic Academia de La Milagrosa. In the grounds of the Pablo Casasús College is placed the historical Iglesia Central Presbiteriana and at its entrance is located El Quenepo used to divide Mayagüez downtown streets in North, South, East and West. At El Quenepo junction the "Mayagüez Urbano" público cars generally turns southbound on their service route along the Ramón Emeterio Betances Street in way to Mayagüez Mall. Across the Méndez Vigo, Candelaria, Ernesto Ramos Antonini, Santiago R. Palmer and Luis Muñoz Rivera streets is the busiest commercial zone of the Mayagüez city center. From here is easy come to the Plaza de Colón with the municipal complex of Teatro Yagüez, Centro Cultural Baudilio Vega Berríos and the Alcaldia de Mayagüez. Between the Luis Muñoz Rivera and San Vicente streets is the Betances House, where was placed the home of Dr. Betances in Mayagüez during the cholera epidemic of 1856. The intersection with San Vicente Street marks the southern end of the historical downtown zone and the entrance to a zone of low-density commercial zone with old warehouses, the former Teatro San José, the intersection with Nenadich Street next to Centro Gubernamental and the entrances to Buena Vista and Colombia sectors, the Asilo de Ancianos, the Municipal Sport and Recreation Department and the Old Municipal Cemetery. Just at this cemetery is the junction with Hiram David Cabassa Street, where the Ramón Emeterio Betances Street climb a hill where is the Belmonte urbanization, the Funeraria Martell, Cementerio Vivaldi and the entrance to Cuesta de las Piedras Housing Project. Next is placed the entrance to Río Cristal clusters, and forward are placed the Escuela Superior José De Diego and the Pontifical Catholic University of Puerto Rico at Mayagüez. After the PUCPR are the entrance to some residential zones, the Channel 3 studios, Escuela Libre de Música" Ernesto Ramos Antonini, the Jardines de Mayagüez Housing Project'' and after crossing a creek, the Barriada Nadal community at Carolina Street. The final section of the Ramón Emeterio Betances Street is through the Poblado Sábalos, reaching this street its finish in a junction with Avenida Corazones in Sábalos ward. Near here is the southern hub of PR-2 where are placed nearby the DTOP/CESCO regional offices, the Police of Puerto Rico regional headquarters, the new municipal cemetery and a shopping center. This street was named by disposition of the Municipal Legislative as a homage to the independence advocate and abolitionist leader Dr. Ramón Emeterio Betances.
