CDC34
CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates for ubiquitin mediated degradation.
Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.Interactions
CDC34 has been shown to interact with CSNK2B, BTRC and CDK9.
