Business Loop I-44 through Sarcoxie begins running south from I-44 concurrent with Route 37 It then splits off at Blackberry St., which becomes High Street upon entering Sarcoxie. After leaving the town, BUS I-44 angles northeast and ends at I-44. This road is part of former U.S. Route 166 which preceded I-44 through the area.
Business Loop I-44 in Mount Vernon runs along Mt. Vernon Rd. The east half of the highway is concurrent with Route 39. This was largely along the route of US 166.
Springfield business loop
Business Loop I-44 in Springfield begins at the eastern terminus of Route 266 and runs east along Chestnut Expressway, intersecting U.S. Route 160 and Route 13. It then runs along the north edge of downtown Springfield. I-44 BUS turns north at Glenstone Avenue, bumping Business Route 65. It then ends where Glenstone meets I-44.
Lebanon business loop
Business Loop I-44 in Lebanon begins at the westernmost Lebanon exit and ends at the easternmost exit. The route follows former U.S. Route 66 its entire length. Business I-44 follows Springfield Road, then curves off and becomes Elm Street. At Jefferson Street is a junction with Routes 5, 32, and 64.
Waynesville-St. Robert business loop
Business Loop I-44 in the Waynesville-St. Robert area begins on the west side of Waynesville at Exit 156. The road briefly heads north on Ichord Avenue, then heads east in a duplex with Route 17. The road, at this point, also becomes Historic Route 66. Business I-44 continues east, past the Pulaski County Courthouse in the old part of the city. The route then climbs a steep hill, and rounds a curve underneath a rock overhang painted like a frog. Business I-44 continues into St. Robert, the lanes split with a Roadside Park between them. It pass on through St. Robert, ending at Exit 161, which is also the exit for Business Spur I-44. ;Major intersections
Business Spur I-44 is a short route connecting Business Loop I-44 in St. Robert with the main north gate of Ft. Leonard Wood. The highway is lined with businesses and is also called Missouri Avenue, whose name continues into Ft. Leonard Wood. It is an old alignment of Route 17. ;Major intersections
Rolla business loop
Business Loop I-44 in Rolla begins at the westernmost Rolla exit and ends at the easternmost exit. The route follows US Route 66 its entire length. The road is Kingshighway to Bishop Avenue, where the road joins northbound US 63, with which it is duplexed to I-44. Near the Missouri University of Science and Technology is a model of Stonehenge.
Pacific business loop
Business Loop I-44 is a former routing of U.S. Route 66 through downtown Pacific, Missouri. This portion of road is designated a Business Loop after Interstate 44 was built to bypass the town. U.S. Route 50 was then rerouted onto Interstate 44, making this portion a Business Loop after US 66 was removed from the area in 1979. After the Business Loop's western terminus, the road continues solely as Historic U.S. Route 66 until an intersection with Route 100.
