After completing his studies in mathematics and physics in 1982, Brandenburg began programming3Dcomputer games on the Commodore 64, Apple II and later the IBM PC and Amiga. Brandenburg started several technology companies that were later acquired by private and public corporations. In 1984, he co-founded Sculptured Software and led the company as President. The company was eventually sold for almost US$40 million after producing dozens of titles for the C64, Atari ST, Commodore Amiga, IBM PC and Apple II. In 1994, Brandenburg started another game company, Software Arts International that was acquired in 1996 by Engineering Animation, Inc., where he was the Executive Producer for the public company's Interactive Division, producing titles for Disney, Mattel, Hasbro Interactive and Sierra On-Line. In 1999, Bryan Brandenburg partnered with Karl Malone to build a media-centric outdoors media company with websites, a television show, a radio program, a monthly magazine, and a book publishing arm. The company was acquired in 2001. Brandenburg was an executive officer of DAZ 3D, a 3D content company and launched Bryce in July 2004. In January 2005, he was recruited as the CEO of Zygote Media Group and launched Male Anatomy Collection 2.0, the 3DScience.com website, Female Anatomy Collection 3.0 and Zygote Heart 3.0. In 2006, Brandenburg partnered with Content Paradise produce a current 3D model of the solar system including planets, moons and asteroid field. Brandenburg is the co-founder of Salt Lake Comic Con. As Chief Marketing Officer, he announced a global partnership with PopLife Entertainment, the company that distributes the big-headed Funko Pop! figures in Asia, to bring FanX events to China, Thailand and the Philippines. In November 2017, he was inducted in the Honorary Commander program for the 419th Fighter Wing at Hill Air Force Base. In 2019 Bryan Brandenburg announced Zenerchi, a biomedical simulation and visualization AI company after raising $1.2 million in seed funding. Brandenburg announced an international partnership with Pop Life Global in December 2019 to produce a series of exhibitions called The Human Xperience.
