Prior to turning professional, Manning played major junior hockey in the Western Hockey League with the Chilliwack Bruins. On November 23, 2010, during the 2010–11 season with Chilliwack, the Philadelphia Flyers signed Manning as an undrafted free agent. On March 8, 2012, after playing 32 games for Adirondack Phantoms in 2011–12 AHL season, he was called up to the Flyers main roster to replace injured Pavel Kubina. He made his NHL debut the same day in a home game against Florida Panthers. On August 27, 2014, Manning signed a one-year contract to stay with the Flyers. On March 21, 2016, Manning scored his first career NHL goal against Thomas Greiss of the New York Islanders. On December 8, 2016, during a game against the Edmonton Oilers, Oilers star Connor McDavid claimed Manning boasted on-ice that he intentionally broke McDavid's collarbone the year before which had sidelined McDavid for 37 games, which he labelled as "classless" in a post game interview. Manning denied the claim. On February 27, 2017, Manning was suspended two games for interference against Jake Guentzel. Manning concluded the 2016–17 season with 12 points in 65 games. During the 2017–18 season, Manning recorded a career-high 7 goals and 19 points in 65 games to help the Flyers qualify for the 2018 Stanley Cup playoffs. The Flyers ended up losing in 6 games to the Pittsburgh Penguins. On July 1, 2018, Manning left the Flyers as a free agent and agreed to a two-year contract with the Chicago Blackhawks. He began the 2018–19 season on the Blackhawks third defensive pairing, adding 1 goal and 2 assists in 27 games before he was traded by Chicago, along with Robin Norell, to the Edmonton Oilers in exchange for Drake Caggiula and Jason Garrison on December 30, 2018. Manning scored 1 goal in 12 games with the Oilers, before on February 18, 2019, he was placed on waivers by the Oilers and later re-assigned to AHL affiliate the Bakersfield Condors. While with the Condors, Manning was suspended for five games for using a racial slur against Boko Imama of the Ontario Reign. During his second game after the suspension, Manning lost a fight to Imama.
