Kirsch, attended Cedar Crest High School in Lebanon, Pennsylvania, where he was first team all-state, first team all-county and league Most Valuable Player as senior after completing 115 of 198 passes for 1,950 yards and 26 touchdowns. He also rushed for 515 yards on 88 carries and two touchdowns. Brandon was named second team all-county both his sophomore and junior seasons and was honorable mention all-state as junior. He completed 104 of 186 passes for 1,595 yards and 20 touchdowns as junior and 78 of 162 passes for 1,178 yards and 14 touchdowns as sophomore. Career totals were 300 of 552 passing for 4,808 yards and 61 touchdowns with 241 rushes for 1,142 yards and 10 touchdowns. His high school football coach was Gene Fuhrman. He also played baseball and basketball. On September 24, 2001, he signed a letter of intent to play quarterback at Purdue University. He was ranked a 4-star prospect according to Rivals.com.
College career
Kirsch started four games in 2002 as a true freshman, completing 59.0 percent of his passes for 1,067 yards with 8 touchdowns and 5 interceptions. He was also third on the team in rushing with 423 yards. Kirsch appeared in only three games his sophomore season before injuring his throwing shoulder and taking a medical redshirt. He returned in 2004 and started six games, throwing for 1,625 yards with 7 touchdowns and 7 interceptions in those games, before being benched in favor of freshman Curtis Painter. Following the benching, Kirsch caused a controversy on the team and lost popularity among fans and teammates. Kirsch chose to not return to school for his senior season, declaring himself for the 2006 NFL Draft.
Kirsch was rated the 21st quarterback in the 2006 NFL Draft by NFLDraftScout.com.
Colorado Crush
He was not drafted by the NFL and signed with the Arena Football League's Colorado Crush. Spent two seasons with the Crush, where he played four total games, completing 12-of-21 passes for 179 yards and 2 touchdowns.
Philadelphia Soul
On May 20, 2011, the Philadelphia Soul signed Kirsch to fill in for Justin Allgood, who was traded to the Tulsa Talons. On June 19, 2011, it was announced that he would start in place of the struggling Ryan Vena.
