Blepharophimosis, ptosis, epicanthus inversus syndrome


Blepharophimosis, ptosis, epicanthus inversus syndrome is a rare disease characterized by the conditions it is named after: blepharophimosis, ptosis and epicanthus inversus. There are two types; type 1 is distinguished from type 2 by including the symptom of premature ovarian insufficiency in females, which causes menopausal symptoms and infertility in patients as young as 15 years old.

Signs and symptoms

The most prominent symptoms of BPES are horizontally narrow eyes, drooping eyelids and a fold of skin running from the side of the nose to the lower eyelid. Other common symptoms include lack of an eyelid fold, an appearance of widely spaced eyes, low nose bridge and ear malformations. Rare symptoms include microphthalmos, tear ducts in the wrong location and a high-arched palate. Type 1 BPES is distinguished by including premature ovarian insufficiency in females, which causes menopausal symptoms and infertility in patients as young as 15 years old.

Genetics

BPES is caused by a mutation in the gene FOXL2, located at 3q23. There are two types, caused by different mutations in this gene, but both follow an autosomal dominant pattern of inheritance.

Diagnosis

Though BPES can be suggested by the presence of blepharophimosis, ptosis and/or epicanthus inversus, it can only be definitively diagnosed by genetic testing. Other disorders that appear similar include Waardenburg syndrome and Ohdo blepharophimosis syndrome.

Treatment

The main treatment is symptomatic, since the underlying genetic defect cannot be corrected as of 2015. Symptomatic treatment is surgical.

Epidemiology

BPES is very rare: only 50–100 cases have been described. It affects slightly more males than females.