The original version of the strip was drawn by David Sutherland and ran in distinct series from issue 1289 to 1677. Despite its seven-year run there was no direct indication of the origins of the crime-fighting schoolchildren apart from the occasional reference to William's late father, noted to be an inventor, presumably having developed the cat-suits, helmets, lasso ropes and cat claws etc. An unofficial origin of Billy the Cat and Katie written by David Carman is available to read online. When the strip made the final appearance of its original run in 1974, it was one of the last remaining adventure strips in the Beano. An older version of Billy, without Katie, and now set in Marham, appeared in Buddy comic in the 1980s. Minus Katie, the strip returned to The Beano for six weeks from issue 3195, dated 11 October 2003, drawn by Wayne Thompson and Richard Elson. In 2005, it made a second brief return, scripted by Mike Chinn and this time drawn by Nigel Dobbyn, who has also subsequently drawn several Billy and Katie stories for Beano Annuals, from the 2007 annual onwards. The story in that annual was written by Bash Street Adventures artist/writer Kev F Sutherland. The 2009 annual did not have a Billy the Cat story, though he reappeared in the 2010 annual, starring "William the cat" in a Victorian setting which turns out to be the hallucination of an unconscious William Grange, on a school trip to a museum. He made a guest appearance in the 70th anniversary Beano in 2008, this time drawn in a Manga-like style by Laura Howell. Billy returned to the comic shortly after in issue 3454, as a single-page strip illustrated by Barrie Appleby. Despite this, Nigel Dobbyn's version of the strip appeared in the Beano Annual 2011 . However, Dobbyn was unhappy with how his artwork had been stretched in that year's annual, and as a result Billy did not appear in the 2012 annual.
This was a crossover between Billy the Cat and General Jumbo in the 2008 Beano Annual written by Kev F Sutherland and drawn by Nigel Dobbyn. It involved Jumbo's radio control having been modified by a sentient model infantryman, taking control of Jumbo's actions. Billy had to save the day, firstly by removing Jumbo's wrist-controller and secondly by causing it to feed back on its creator – who, however, in homage to a classic B-movie motif, shows faint signs of life in the final panel while the heroes make their exit. This story was concluded in the 2009 annual, again written by Sutherland, but this time only featured Jumbo and was drawn by another artist.
