Schoolteacher and family man Ed Avery, who has been suffering bouts of severe pain and even blackouts, is hospitalized with what is diagnosed as polyarteritis nodosa, a rare inflammation of the arteries. Told by doctors that he probably has only months to live, Ed agrees to an experimental treatment: doses of the hormone cortisone. Ed makes a remarkable recovery. He returns home to his wife, Lou, and their son, Richie. He must keep taking cortisone tablets regularly to prevent a recurrence of his illness. But the "miracle" cure turns into a nightmare when Ed begins to misuse the tablets, causing him to experience wild mood swings and, ultimately, a psychotic episode which threatens the safety of his family.
Bigger Than Life was not a financial success. Mason, who produced the film as well as starring in it, blamed its failure on its use of the then-novel widescreen CinemaScope format. American critics panned the film, considering it melodramatic and heavyhanded. Bosley Crowther of The New York Times called it tedious, "dismal", and "more pitiful than terrifying to watch". However, the film was popular with critics at the influential magazine Cahiers du cinéma. Jean-Luc Godard called it one of the ten best American sound films. Likewise, François Truffaut praised the film, noting the "intelligent, subtle" script, the "extraordinary precision" of Mason's performance, and the beauty of the film's CinemaScope photography. Modern critics have pointed out Ray's use of widescreen cinematography to depict the interior spaces of a family drama, rather than the open vistas typically associated with the format, as well as his use of extreme close-ups in portraying the main character's psychosis and megalomania. The film is also recognized for its multi-layered examination of the Americannuclear family in the Eisenhower era. While the film can be read as a straightforward exposé on medical malpractice and the overuse of prescription drugs in modern American society, it has also been seen as a critique of consumerism, the male-dominatedtraditional family structure, and the claustrophobic conformism of suburban life. Truffaut saw Ed's drug-influenced speech to the parents of the parent-teacher association as having fascist overtones. The film has also been interpreted as an examination of masculinity and a leftist critique of the low salaries of public school teachers in the United States. In 1998, Jonathan Rosenbaum of the Chicago Reader included the film in his unranked list ofthe bestAmerican films not included on the AFI Top 100.