During his early career, Brown traveled and worked in St. Louis, Little Rock and Texas. In St. Louis, Brown taught at the St. Louis Art School. He went on to open his own school in Little Rock. He initially specialized in portraiture and still life. Upon moving to Pasadena in 1896, he began to paint landscapes. John Bentz gave him his first show in Pasadena at the Hotel Green, although He didn't sell any artwork until about 1900, but by 1905 he had become famous for his paintings of poppies. From 1909 to 1910, Brown had a studio in Mill Valley, California. He frequently held exhibitions in northern California and areas around San Francisco. His first etchings were done in 1914. He co-founded the Print Makers of Los Angeles with his brother Howell in 1914, which later became the Los Angeles Society of Printmakers. His notable works include his impressionist landscapes of Sierra peaks and field poppies. Due to the high demand for his works, he sent out lantern slides instead of paintings. Brown tried to sell his artwork in New York City; however, it did not sell as well as it had in California. Instead of opening a studio in the city, he began to sign California under his own signature to show how proud he was to be a Californian, in spite of potential stigmas. Brown was a member of the Pasadena Society of Artists, the California Art Club, the Chicago Society of Etchers, the American Federation of the Arts, and the Laguna Beach Art Association. He showed at the Del Monte Art Gallery before 1914. He also had solo exhibitions at the Los Angeles County Museum of Art in 1915, 1917, and 1918. He showed a group exhibition there in 1929. His work also appeared at the Oakland Art Gallery in 1932.
By 1925, Brown's health was declining. Therefore, the amount of art he could continue to produce declined. In 1929, he had an abscessed tooth and lost a lot of weight because it was too painful to eat. This ailment impeded his painting. Although his health did improve in the 1930s, He served as the president of the California Society of Printmakes until 1929. Brown died of pneumonia on January 19, 1942 in Pasadena. Brown's works are held by the Smithsonian Institution, the Library of Congress, Oakland Museum of California, the Los Angeles, California Municipal Art Collection, the Montclair, New Jersey Museum, the Cleveland, Ohio Museum, the Boise, Idaho Public Library, and other public libraries throughout the country. He is remembered as one of the first artists to paint in Pasadena.