In 1517, Beit Imrin was incorporated into the Ottoman Empire with the rest of Palestine. In 1596, it appeared in Ottoman tax registers as a village in the nahiya of Jabal Sami in the Nablus Sanjak. It had a population of 19 households and 2 bachelors, all Muslim, and paid taxes on wheat, barley, summer crops, olive trees, occasional revenues, goats and beehives, and a press for olives or grapes; a total of 13,200 akçe. In 1667 there was a Greek Orthodox community in the village. In 1838 American Biblical scholarEdward Robinson noted that the village was on the road to Jenin. He also noted that the village had a mixture of Greek Christians and Muslim inhabitants. At this time the village had 50 Christians and a priest. In 1870, Victor Guérin estimated that Beit Imrin had 700 inhabitants. He further noted: "The houses are small and roughly built, except the Sheikh’s house, which is large and well-built. Below the village and to the west there is a fertile valley irrigated by a spring called Ain Dilbeh." In 1882, the PEF's Survey of Western Palestine described it as "a village of moderate size in the valley at the foot of the Sheikh Beiyzid chain. It is built of stone, and has a spring in the valley to the south, and olives round it on the east and west. Some of the inhabitants are Greek Christians."
In the 1922 census of Palestine conducted by the British Mandate authorities, Beit Imrin had a population of 527; 512 Muslims and 15 Christians, where the Christians were all Orthodox. The population increased in the 1931 census to 620, of whom 13 were Christians and 607 Muslims, in a total of 157 occupied houses. In the 1945 statistics, the population was 860, all Muslims, with 12,094 dunams of land, according to an official land and population survey. Of this, 1,442 dunams were for plantations or irrigated land, 6,819 for cereals, while 53 dunams were built-up land.
Since the Six-Day War in 1967, the village has been under Israeli occupation. A census that same year recorded the population as 1,100. After the 1995 accords, 97.7% of the village land was classified as Area A, 1.8% as Area B, and the remaining 0.5% as Area C. A village council to administer Beit Imrin's civil affairs was established in 1966, with the first mayor being Ayad Youssef Abdel-Rahman Ahsan. The council consists of nine members including the mayor, who currently is Basheer Samarah.