Effendi was the younger brother of Rustam Effendi, a communist-sympathising poet born in 1903. Their family was originally from Padang, West Sumatra, although the brothers left Padang for their education. Effendi dropped out of senior high school – a level of schooling already more than most native children received – and instead of becoming a law student as his parents intended he became a labourer at Tan's Film, working in decor. Effendi acted in his first acting role in 1930 with Si Ronda. He then became an assistant director with Melati van Agam, also taking a minor acting role. He directed his first film, the talkieNjai Dasima, in 1932, becoming the first native Indonesianfilm director in the Indies. After, he left Tan's to replace Andjar Asmara as editor in chief of Doenia Film, a Malay-languagefilm magazine. Effendi joined the Dardanella theatre troupe in 1936, working as an actor. Andjar served as a dramatist. In 1936 the two left Dardanella to establish the Bollero troupe, and sometime later Effendi married Suhara, the sister of Andjar's wife Ratna. After Andjar left the troupe in 1940 to work for The Teng Chun's Java Industrial Film, Effendi remained leader of Bollero, which became increasingly politicised and vocal against the widespread corruption of the time. During this time he married Zuhara.
Post-independence
The troupe stayed in Malacca until 1945; aside from his work with Bollero, Effendi was involved with the domestic film industry and became a "culture warrior" in the press. Effendi was arrested in Singapore for refusing to support the British, but after his release he acted the 1949 filmSeruan Merdeka. He returned to Indonesia – which had declared its independence in 1945 – by 1950 and began directing several films for the National Film Company, including Djiwa Pemuda, a cry for former soldiers to work towards national development. In 1955 Effendi served as press attaché in Italy. In the late 1950s he stated his support for the Revolutionary Government of the Republic of Indonesia, an ill-fated attempt at a revolution. After the PRRI was quashed, Effendi chose to stay in Italy, reportedly taking bit parts in Italian films. After Sukarno's government lost power in the 1960s, Effendi began occasionally returning to Indonesia, partly to visit his family, partly to act, and partly to ease Italian-Indonesian cooperation. He died in Rome on 1 April 1976.