BCL3
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.Interactions
BCL3 has been shown to interact with:
- BARD1,
- C-Fos,
- C-jun,
- C22orf25,
- COPS5,
- EP300,
- HTATIP,
- NFKB1,
- NFKB2,
- PIR, and
- NR2B1.
