Appalachiosaurus is so far known from only partial remains, including parts of the skull and mandible, as well as several vertebrae, parts of the pelvis, and most of both hindlimbs. These remains are housed at the McWane Science Center in Birmingham, Alabama. There are several open sutures between bones of the skull, indicating that the animal was not an adult. Several elements are crushed, but the specimen is still informative and shows many unique characteristics, or apomorphies. Several of these apomorphies have been identified in the skull, and the claws of the feet show an unusual protrusion on the end closest to the body. A row of six low crests lines the top of the snout, similar to the Asian Alioramus, although most tyrannosaur species exhibit ornamentation to varying degrees on top of the snout. The only remains found are from a juvenile, meaning that the size and weight of the adult is not known. Appalachiosaurus is significantly different and more derived than another early tyrannosaur from eastern North America, Dryptosaurus. The forelimbs of Appalachiosaurus are poorly known. Large tyrannosaurids are characterized by proportionally small forelimbs and hands with two functional digits each; except some reports of a humerus ascribed to Appalachiosaurus, no forelimb material are known. Early reconstructions gave it long arms with three fingers, but they are now thought to have been much shorter, with only two fingers. Museum mounts have been corrected accordingly. Appalachiosaurus had a bite force of around 32,500 newtons, or 7,193 pounds per square inch.
Classification
The only known specimen Appalachiosaurus was complete enough to be included in phylogenetic analyses using cladistics. The first was performed before the animal had even been named, and found Appalachiosaurus to be a member of the albertosaurine subfamily of Tyrannosauridae, which also includes Albertosaurus and Gorgosaurus. The original description also included a cladistic analysis, finding A. montgomeriensis to be a basal tyrannosauroid outside of Tyrannosauridae. However, Asian tyrannosaurs like Alioramus, and Alectrosaurus were excluded, as was Eotyrannus from England. Earlier tyrannosaurs such as Dilong and Guanlong had not been described at the time this analysis was performed. These exclusions may have a significant effect on the phylogeny. Below is a cladogram published in 2013 by Loewen et al..
Possible pathology
Two vertebrae of the tail were found to be fused together, possibly a result of new bone growth following some sort of injury.