Anti-Müllerian hormone receptor
Anti-Müllerian hormone receptor is a receptor for anti-Müllerian hormone. Anti-Mullerian hormone receptor type 2 is a protein that in humans is encoded by the AMHR2 gene.Function
This gene encodes the receptor for the anti-Mullerian hormone which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. .Pathology
The anti-Müllerian hormone receptor can be responsible for persistent Müllerian duct syndrome.
Müllerian inhibiting substance type II receptor, also known as the Anti-Müllerian Hormone Receptor, is expressed by ovarian, breast, and prostate cancers and these cancer cells have been reported to apoptose in response to exposure to the Müllerian inhibiting substance.
Antibodies have been developed that specifically target MISIIR and may be useful as vehicles for drugs and toxins for targeted cancer therapy.
