Born in Ferentino, Angelo Palombo began playing football for local side AS Ferentino. He spent the 1997–98 season with Serie D club Urbania Calcio. At age 17, he moved to Serie C team Fano before being signed by Serie A side Fiorentina in 1999 where he spent two years playing for the Primavera team of the club. He made his professional debut in a Coppa Italia match against Como and first featured in the Serie A on 10 February 2002 in a 2–0 away defeat against Venezia.
Palombo moved to Sampdoria, then in Serie B, on a free transfer in the 2002 summer transfer window when Fiorentina declared bankruptcy and were forced to put their players on sale. After helping the Ligurian club gain promotion that season, he established himself as an integral part of the side. During the 2005–06 season, he scored his first Serie A goal for Sampdoria on 18 January 2006 against his boyhood club Fiorentina and made his European debut in the UEFA Cup in September. Palombo had many very good seasons at the club, leading to him being a regular in the Italian national team. When Sampdoria were again relegated at the end of the 2010–11 season, his future at the club was put into doubt, with many Serie A sides interested but mainly his former club Fiorentina. Palombo, by then the club's captain, said, however, that he had no intention to move unless the club wished to sell him and remained at the club, commenting: "I'll end my career with Sampdoria. I'm proud to have received some important offers and I thank the clubs who have come forward. However, I haven't thought about leaving here, not even for a moment. I think I have already demonstrated how tied I am to this shirt." He spent the first half of the 2011–12 season in Serie B with Sampdoria, but on 31 January 2012, he was signed by Inter on loan with an option to buy, as a replacement for Thiago Motta. He made his club debut the following day, coming on as a substitute for Andrea Poli in a 4–4 home draw against Palermo. However, he only made three appearances for Inter in total, and returned to Sampdoria at the end of the 2011–12 Serie A season, who had secured a spot back in Serie A for the 2012–13 season. However, it seemed that he was set to leave the club in the summer of 2012, and was even linked with several other Italian sides; after no other offers, he remained with Sampdoria the following season, and until his retirement. He announced his retirement from professional football in July 2017, after collecting 459 appearances for Sampdoria in his 15 years spent at the club.
After retiring from professional football, Palombo joined the coaching team of Marco Giampaolo for the 2017–18 season with his former club Sampdoria. He received his coaching licence on 15 December 2017.
Style of play
Palombo was usually deployed as a defensive or box-to-box midfielder in the centre of the pitch, where he could effectively combine his defensive and athletic attributes, as well as his ability to break down opposition plays, with his ability to start attacking plays and create chances for teammates as a deep-lying playmaker; however, his energetic, hard-working style of play and his stamina allowed him to play anywhere in midfield, and he was also deployed as a winger on occasion. In addition to his ball-winning and passing abilities, he also possessed a powerful shot from distance. Palombo was a physically strong, tenacious, influential, and determined player, with good feet, who was also known for his passion and good quality of play on the pitch; however, he was also accused by certain pundits of inconsistency at times throughout his career. In his youth, Palombo cited Demetrio Albertini as one of his major influences.
