Amnon Yitzhak was born to Yahya Zechariah Yitzchak and Rumia Yitzchak in Tel Aviv, Israel to a Yemenite Jewish family. He was brought up in a non-religious home, and became religious at the age of 24, after stumbling across the seferKitzur Shulchan Aruch, that he received for his Bar Mitzvah. In 1986, he established the non-profit organization 'Shofar' for promoting the "return to religion" among the Jewish Israeli population. His lectures and other activities have made Yitzhak a prominent Israeli rabbi since the early 1990s. Through 'Shofar', Yitzhak has launched two widely distributed weekly newspapers, Arba Kanfot and Shofar News geared to the Haredi public and general public respectively. They ceased publication in 2008.
Yitzhak has also addressed the issue of the secular Zionist leadership, and has released, for example, a video titled "Herzl and Zionism", which presents a critical view of both. Yitzhak has said, referring to Theodore Herzl, "There have been two great criminals in the history of the Jewish people: Hitler and Herzl. Hitler wanted to destroy the body of the Jewish nation. Herzl wanted to kill the soul, which is far more important than the body." In a cassette titled "In the Shadow of Democracy", he strongly criticizes the State of Israel and the leadership for their attitude towards the Mizrahi-traditional and Haredi Jewish public, especially during the period of the Holocaust. According to Avishai Ben Haim, Ynet correspondent on Jewish Religious Affairs, Yitzhak "is considered to have a clear anti-Zionist position, similar to that of the Satmar Hasidim. Like them, he boycotts the Knesset elections. This view is extremely rare among the Haredi-Mizrahi public, and even rarer among Mizrahi newly-observant Jews - Amnon Yitzhak's primary target audience." Nonetheless, he had announced his guiding and leadership of the Israeli political partyKoah Lehashpi'a for the 2013 Knesset elections in late November 2012. His party did not pass the election threshold, and therefore did not enter to the 19th Knesset. The party received 28,000 votes.
Views on women
In 2013, Yitzhak asserted that women should not drive cars, claiming "It is immodest for a woman to drive".