The All of UsResearch Program is a research program created in 2015 during the tenure of Barack Obama with $130 million in funding that aims to make advances in tailoring medical care to the individual. The mission of AoU is to accelerate health and medical breakthroughs, enabling individualized prevention, treatment and care from all of us. The project aims to collect genetic and health data from one million volunteers. The initiative was announced during the 2015 State of the Union Address, and is run by the National Institutes of Health. The founding program director was Eric Dishman, who stepped down to become the Chief Innovation Officer. In 2019, Joshua Denny was selected to be the second director. In October 2016, the project was renamed "All of Us". The research program was launched for national enrollment on May 6, 2018. The Program is currently bilingual, with information and materials available in Spanish and English. Additional languages will be added in the future.
Core Values
A set of All of Us core values are guiding the development and implementation of the All of Us Research Program:
Participation is open to all.
Participants reflect the rich diversity of the U.S.
Participants are partners.
Trust will be earned through transparency.
Participants have access to their information.
Data will be accessed broadly for research purposes.
Security and privacy will be of the highest importance.
The program will be a catalyst for positive change in research.
What Data is Collected
When you sign up for the All of Us Research Program, you are asked to take a survey that gathers information about your lifestyle and environment. Participants in All of Us can choose to give researchers access to their electronic health records, which includes information about their individual health problems and treatment they have received. They may also be asked to provide blood and urine samples and your physical measurements. Participants may also share data gathered by wearable devices and in the future be asked to participate in clinical trials. Program leaders plan to capture genomic data from select participants in 2019.
Who Can Enroll
Eligible adults can enroll with the program. People who are not eligible are those in prison or people who cannot consent on their own According to a sample consent form released in June 2018, participation in All of Us is voluntary and does not affect a participant's medical care. The form explains that if a participant quits the program, their samples will be destroyed. Children may also be able to enroll in the program. By January 2018 an initial pilot project had enrolled about 10,000 people and 2022 was targeted for one million people. As of May 2019, enrollment numbers at 1-year launch anniversary are 187,000+ participants, with more than 132,000 who have given biosamples. The NIH reported in May 2018 that they were pleased with high enrollment by underrepresented groups including communities of color and individuals with lower incomes. Up to three-quarters of beta phase participants came from those communities.
Program Partners
All of Us has more than 100 partners and champions working together to implement and support the mission and goals of the research program. Google life sciences startup Verily Life Sciences, a Google "moonshot" with a goal of "transform the way we detect, prevent, and manage disease" is one partner. The initiative was identified by a 2019 review as involving the public in every stage of the research.
Program Budget
The All of Us Research Program budget has increase every year since it launched: FY2016 - $130 million; FY2017 - $230 million; and FY2018 - $290 million.
In the summer of 2019, one year after its official launch, All of Us had enrolled 230,000 participants, which represents almost one quarter of the program's goal of 1,000,000 individuals. Approximately 80% of those people are from groups that have been traditionally underrepresented in biomedical research. One of All of US's main goals is to include many people from diverse ancestries. By June 2020, enrollment reached approximately 350,000 individuals.
All of Us Researcher Workbench
On May 27, 2020, the All of Us research program announced the launch of their research platform, the All of Us Researcher Workbench, for beta testing. Select data collected by the initiative, including electronic health records and survey responses from the first 225,000 program participants, will be available to approved researchers through the workbench. Researchers may apply for access to the data if they have an NIH eRA Commons account and are affiliated with an institution that has signed a data use agreement with All of Us.
Response to COVID-19 Pandemic
In June 2020, the NIH announced that research materials collected as part of the All of Us initiative will be used to address the COVID-19 pandemic. Blood samples collected from recent volunteers will be tested for SARS-CoV-2antibodies in order to track prior infections within the US population. Electronic health records shared by All of Us participants will also be evaluated for potential patterns associated with SARS-CoV-2 infection. All of Us also added monthly participant surveys with questions about the physical, mental, and socioeconomic impacts of the COVID-19 pandemic.
