The vilayet was established in March 1866. The new boundaries of Aleppo were stretched northward to include the largely Turkish-speaking cities of Maraş, Antep and Urfa, giving the province a roughly equal number of Arabic- and Turkish-speakers, as well as a large Armenian-speaking minority. Thanks to its strategic geographic location on the trade route between Anatolia and the east, Aleppo rose to high prominence in the Ottoman era, at one point being second only to Constantinople in the empire. However, the economy of Aleppo was badly hit by the opening of the Suez Canal in 1869, and since then Damascus rose as a serious competitor with Aleppo over the title of the capital of Syria. Historically, Aleppo was more united in economy and culture with its sister Anatolian cities than with Damascus. This fact still shows today with the distinctive cultural differences between Aleppo and Damascus. At the end of World War I, the Treaty of Sèvres made most of the Province of Aleppo part of the newly established nation of Syria, while Cilicia was promised by France to become an Armenian state. However, Mustafa Kemal Atatürk annexed most of the Province of Aleppo as well as Cilicia to Turkey in his War of Independence. The Arab residents in the province supported the Turks in this war against the French, a notable example being Ibrahim Hanano who directly coordinated with Atatürk and received weaponry from him. The outcome, however, was disastrous for Aleppo, because as per the Treaty of Lausanne, most of the Province of Aleppo was made part of Turkey with the exception of Aleppo and Alexandretta; thus, Aleppo was cut from its northern satellites and from the Anatolian cities beyond on which Aleppo depended heavily in commerce. Moreover, the Sykes-Picot division of the Near East separated Aleppo from most of Mesopotamia, which also harmed the economy of Aleppo. The situation exacerbated further in 1939 when Alexandretta was annexed to Turkey, thus depriving Aleppo from its main port of İskenderun and leaving it in total isolation within Syria.
Demographics
At the beginning of the 20th century it reportedly had an area of, while the preliminary results of the first Ottoman census of 1885 gave the population as 1,500,000. The accuracy of the population figures ranges from "approximate" to "merely conjectural" depending on the region from which they were gathered.