Ek Thi Misal highlights the situation of the young lady Misal, whose perfect world is flipped around on account of the desire and envy of her close relative and grandma, prompting to her parents' separation. It is concurred that Misal will spend 15 days of the month with her dad, and the rest of the 15 with her mom. Here begins the predicament and hardships of Misal as her life swings between her mom's and dad's homes. Both her parents remarry to go ahead with their lives yet for Misal, the sentiment dismissal from her parents and hatred of her step-mother, step-father and whatever is left of the family develops with each passing day.
Characters
First Generation
; Adeel : Adeel is the male protagonist and Misaal's Father. He married Bushra. The couple had a Daughter Misaal. The couple separated because of dispute. He then married Iffat. ; Bushra : Bushra is the female protagonist and first wife of Adeel. She had a daughter Misaal. They were separated because of disputes between her and her husband Adeel. She later married Ahsan. She had a daughter Rania. ; Iffat : Iffat is the second wife of Adeel. She always disliked Misaal and her mother Bushra. She thinks that Adeel had always loved Misaal more than her and her children but Adeel had always kept everyone equal. ; Aasma: was the teacher of Misaal and the mother ofWasik and Warda. ; Waqar : Waqar is the friend of Adeel and father of Fahad. He moved his proposal forward of marrying his son with Adeel's daughter Misaal. The Nikah was not accepted as Fahad had already married a woman Laila and has a daughter.
Second Generation
; Misaal : : Misaal is the daughter of Adeel and Bushra. Misaal was first liked by her foster brother Saifi. Ahsan finally sent Misaal from his home. Misaal now lived with her father and his second wife Iffat and her children. Iffat always disliked Misaal as her father liked her more than her daughter and son. Iffat became happy after her engagement with Fahad. The Nikah was cancelled at the last moment because Fahad had already married Laila and had a daughter. Wasik took proposal of marrying Misaal, Adeel accepted. The problems between Wasik and Pari let Wasik hate with Misaal. ; Fahad : Fahad is the son of Waqar. He married Laila and spend more time in office works. Adeel decided to marry his daughter to Waqar's son Fahad. Waqar kept his son's marriage with Laila a secret to Adeel. This made Adeel angry with Waqar. ; Dani : Dani also known as Daniyal, is the son of Adeel through his second wife Iffat. He was a careless spoiled boy and a smoker. He always failed in his studies and made his father angry. ; Rania : Rania is the daughter of Bushra, through her second husband Ahsan. She is half sister of Saifi. She is the half sister of Misaal. ; Saifi : Saifi is the son of Ahsan and his first wife. He is half brother of Rania. He is the foster brother of Misaal. He always liked Misaal. He always misbehaved with Misaal. ; Wasik : Wasik is the son of Misaal's teacher. When Misaal first time came into her teacher's home. Wasik saw her and liked her. He said that she will be his first and last love but Misaal ignored him. Wasik was liked by Pari, daughter of Iffat but Wasik didn't like Pari. She later disliked Misaal as Wasik married Misaal. ; Warda : Warda is the daughter of Misaal's teacher and sister of Wasik. She disliked Misaal as she was Pari's best friend and Warda always wanted her brother Wasik to marry Pari.
Deaths in Drama as an acting
In its last episode, several acting deaths took place. ; Ahsan's death: He had heart failure and suddenly died before his daughter Rania's marriage. ; Shehzad's father's death: As we know that Shahzad's father stole Wasik's family's money. He didn't used to sleep correctly and all his life he was in guilt, as a result he died after taking too much stress. ; Pari's critical health: Pari had done too much to separate Wasik and Misaal. Saifi gunned her and forced to sleep with him, Pari refused, Saifi hit her with a gun and raped her. ; Misaal's critical health: Pari's plan succeeded this time, separating Misaal and Wasiq through Misaal's half-brother Saifi. Saifi lied and told Wasiq that your wife loves me, Wasik didn't believe his wife and hit her, Misaal fell and got unconscious, as a result was admitted, later she got cured. Misaal's Maternal and Paternal Grandmother also died but there is no proper reason of their deaths.