ARHGAP8
Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.Function
This gene encodes a member of the RHOGAP family. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active and inactive state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.
