ANTH domain


The ANTH domain is a membrane binding domain that shows weak specificity for PtdInsP2. It was found in AP180 endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Its structure is a solenoid of 9 helices. The PtdInsP2 binding residues are spread over several helices at the tip of the structure. The PtdInsP2 binding sequence is Kx9Kx.
An ANTH domain is also found in HIP1 and HIP1R, and the PtdInsP2 binding sequence is conserved. More information is found on .

Human proteins containing this domain

; HIP1R; PICALM; SNAP91;