AM-1714

AM-1714 is a drug that acts as a reasonably selective agonist of the peripheral cannabinoid receptor CB₂, with sub-nanomolar affinity and 490x selectivity over the related CB₁ receptor. In animal studies it has both analgesic and anti-allodynia effects. The 9-methoxy derivative AM-1710 has similar CB₂ affinity but only 54x selectivity over CB₁.

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