AGH-107
AGH-107 is a potent and selective, water soluble and brain penetrant full agonist at the 5HT7 serotonin receptor. The compound is one of the few examples of low-basicity aminergic receptor agonists, which may be a contributing factor in its high selectivity over the related central nervous system targets. The compound readily crosses the blood-brain barrier after intraperitoneal administration and was found to reverse the impairment in novel object recognition caused by MK-801 in mice.
