7,8,3'-Trihydroxyflavone
7,8,3′-Trihydroxyflavone is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor, that was derived from 7,8-dihydroxyflavone. Relative to 7,8-DHF, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist. 7,3’-Dihydroxyflavone is also more potent than 7,8-DHF in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity. 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to 7,8-DHF.
