5-MeO-DALT


5-MeO-DALT or N,N-di allyl-5-methoxy tryptamine is a psychedelic tryptamine first synthesized by Alexander Shulgin.

Chemistry

The full name of the chemical is N-allyl-N- prop-2-en-1- amine. It is related to the compounds 5-MeO-DPT and DALT.
In April 2020, Chadeayne et al. solved the crystal structure of the freebase form of 5-MeO-DALT.

Pharmacology

5-MeO-DALT binds to 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, α2A, α2B, α2C, H1, κ-opioid, σ1 and σ2 receptors with Ki values lower than 10μM and also acts as a DAT and SERT monoamine reuptake inhibitor.
Binding sitepKi ± SEM at binding site
5-HT1A7.70 ± 0.10
5-HT1B6.13 ± 0.04
5-HT1D7.00 ± 0.10
5-HT1E6.30 ± 0.05
5-HT2A6.66 ± 0.08
5-HT2B7.23 ± 0.05
5-HT2C6.34 ± 0.08
5-HT5A5.48 ± 0.04
5-HT66.81 ± 0.03
5-HT77.05 ± 0.07
α2A6.67 ± 0.07
α2B6.14 ± 0.04
α2C5.83 ± 0.06
H16.30 ± 0.06
H35.77 ± 0.04
κOR5.95 ± 0.07
μOR< 5.00
σ16.52 ± 0.06
σ26.60 ± 0.05
DAT5.50 ± 0.20
NET< 5.00
SERT6.30 ± 0.05

The metabolism and cytochrome P450 inhibition of 5-MeO-DALT has been described in scientific literature.

History

The first material regarding the synthesis and effects of 5-MeO-DALT was sent from Alexander Shulgin to a research associate named Murple in May 2004, after which it was circulated online. In June 2004 5-MeO-DALT became available from internet research chemical vendors after being synthesized by commercial laboratories in China. In August 2004 the synthesis and effects of 5-MeO-DALT were published by Erowid.

Dosage

Doses ranging from 12–20 mg were tested by Alexander Shulgin's research group.

Side effects

There is no published literature on the toxicity of 5-MeO-DALT.

Legal Status

China

As of October 2015 5-MeO-DALT is a controlled substance in China.

Japan

5-MeO-DALT became a controlled substance in Japan from April 2007, by amendment to the Pharmaceutical Affairs Law.

United Kingdom

5-MeO-DALT became a Class A drug in the UK on January 7, 2015 after an update to the tryptamine blanket ban.

Singapore

5-MeO-DALT is listed in the Fifth Schedule of the Misuse of Drugs Act and therefore illegal in Singapore as of May 2015.

Sweden

added 5-MeO-DALT to schedule I as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 5-MeO-DALT N-allyl-N--prop-2-en-1-amin.

United States

5-MeO-DALT is not scheduled at the federal level in the United States, but it is likely that it could be considered an analog of 5-Meo-DiPT or another tryptamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.

Florida

5-MeO-DALT is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.

Louisiana

5-MeO-DALT is a Schedule I controlled substance in the state of Louisiana making it illegal to buy, sell, or possess in Louisiana.