321 BC

By place

Macedonian Empire

• Antipater appoints Antigonus commander in chief of his army in Asia Minor and sends him with Craterus to fight against Eumenes, the satrap of Cappadocia and a supporter of Perdiccas.
• Leaving Eumenes to hold Asia Minor against Craterus and Antigonus, Perdiccas marches against Ptolemy, but when he fails to cross the Nile he is murdered by mutinous officers. Prominent among the mutineers is Seleucus. A truce is arranged, leaving Ptolemy in power in Egypt and Seleucus in power in Babylon.
• The key remaining generals of the late Alexander the Great agree to the Partition of Triparadisus. This is a power-sharing agreement providing for a new regent to replace Perdiccas and it repartitions the satrapies of the empire that has been created by Alexander the Great. It follows but modifies the Partition of Babylon made two years earlier following the death of Alexander the Great. Under the agreement, Antipater becomes the regent of the Macedonian Empire on behalf of the two kings: the intellectually retarded Philip III Arrhidaeus and the infant Alexander IV of Macedon while Ptolemy is confirmed in possession of Egypt and Cyrene.
• Ptolemy further strengthens his position amongst the diadochi by marrying Eurydice, the third daughter of Antipater.
• Antigonus and Craterus defeat Eumenes in battle but Eumenes escapes. Antigonus and Craterus then besiege him unsuccessfully in the mountain fortress of Nora on the border between Cappadocia and Lycaonia. Craterus is killed during the fighting against Eumenes when his charging horse falls over him.

  Roman Republic

• Continuing successes by Rome's armies against the Samnites forces the Samnites to sue for peace. However, the terms offered by Rome are so stringent that they are rejected by the Samnites and the war goes on.
• Two Roman consuls, Spurius Postumius Albinus and Titus Veturius Calvinus, leading an invading force into Samnium, are trapped in a mountain pass known as the Caudine Forks near Beneventum, where they can neither advance nor retire, and after a desperate struggle, they are forced to submit to the humiliating terms imposed by the Samnite victor, Gaius Pontius. The captured consuls pledge themselves to a five-year treaty on terms most favourable for the Samnites.

  India

• Chandragupta Maurya, founder of the Mauryan empire, establishes himself as the king of Magadha.