3-Monoacetylmorphine
3-Monoacetylmorphine or 3-acetylmorphine is a less active metabolite of heroin, the other two being morphine and more active 6-monoacetylmorphine.
Because of the acetyl-group in 3-position, 3-MAM has relatively weak affinity to μ-opioid receptors.
As 3-O-acetylmorphine-6-O-sulfate, where 6-OH is changed to 6-O-SO3, it can act as a potent, centrally acting morphine derivative and has important analgesic properties.
making hydroxyl-group in 6-position.
