2010 CAF Champions League group stage
The 2010 CAF Champions League group stage matches took place between 16 July and 19 September 2010. The draw for the two groups took place on 13 May 2010, at the CAF Headquarters in Cairo.
The group stage featured 8 qualifiers from the second round of qualifying.
At the completion of the group stage, the top two teams in each group advanced to the semifinals.
Seeding
The seeding for the group stage was announced on 12 May. Each group consists of a team from each of the 4 pots.| Pot 1 | Pot 2 | Pot 3 | Pot 4 |
 Al-Ahly TP Mazembe |  Heartland ES Sétif | JS Kabylie Dynamos |  Espérance ST Ismaily |
Title Holder
Groups
| Key to colours in group tables |
| Group winners and runners-up advanced to the semifinals |
Group A
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Group B
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Goal scorers
As of 10:34, 20 September 2010| Rank | Player | Club | Total | |||||||||
| 1 | Youcef Ghazali | ES Sétif | 1 | 2 | 3 | |||||||
| 1 |  Given Singuluma | TP Mazembe | 2 | 1 | 3 | |||||||
| 1 |  Michael Eneramo | Espérance ST | 1 | 2 | 3 | |||||||
| 1 | Oussama Darragi | Espérance ST | 1 | 1 | 1 | 3 | ||||||
| 5 | Bouazza Feham | ES Sétif | 2 | 2 | ||||||||
| 5 | Nabil Hemani | ES Sétif | 2 | 2 | ||||||||
| 5 | Dioko Kaluyituka | TP Mazembe | 1 | 1 | 2 | |||||||
| 5 | Mohamed Talaat | Al-Ahly | 1 | 1 | 2 | |||||||
| 5 | Ahmed Ali | Ismaily | 2 | 2 | ||||||||
| 10 | Essaïd Belkalem | JS Kabylie | 1 | 1 | ||||||||
| 10 | Farès Hamiti | JS Kabylie | 1 | 1 | ||||||||
| 10 | Mohamed Khoutir Ziti | JS Kabylie | 1 | 1 | ||||||||
| 10 | Saad Tedjar | JS Kabylie | 1 | 1 | ||||||||
| 10 | Izu Azuka | JS Kabylie | 1 | 1 | ||||||||
| 10 | Nabil Yaâlaoui | JS Kabylie | 1 | 1 | ||||||||
| 10 | Bedi Mbenza | TP Mazembe | 1 | 1 | ||||||||
| 10 | Trésor Mputu | TP Mazembe | 1 | 1 | ||||||||
| 10 | Ndandu Kasongo | TP Mazembe | 1 | 1 | ||||||||
| 10 | Mohamed Aboutrika | Al-Ahly | 1 | 1 | ||||||||
| 10 | Wael Gomaa | Al-Ahly | 1 | 1 | ||||||||
| 10 | Mohamed Nagy | Al-Ahly | 1 | 1 | ||||||||
| 10 | Ahmed Fathy | Al-Ahly | 1 | 1 | ||||||||
| 10 | Mohamed Fadl | Al-Ahly | 1 | 1 | ||||||||
| 10 | Mohamed Barakat | Al-Ahly | 1 | 1 | ||||||||
| 10 | Mohamed Abougrisha | Ismaily | 1 | 1 | ||||||||
| 10 | Ndubuisi Eze | Ismaily | 1 | 1 | ||||||||
| 10 | Mohamed Soliman | Ismaily | 1 | 1 | ||||||||
| 10 | Abdallah El-Shahat | Ismaily | 1 | 1 | ||||||||
| 10 | Moatasem Salem | Ismaily | 1 | 1 | ||||||||
| 10 | Bello Musa Kofarmata | Heartland F.C. | 1 | 1 | ||||||||
| 10 | Ikechukwu Ibenegbu | Heartland F.C. | 1 | 1 | ||||||||
| 10 | Chinedu Efugh | Heartland F.C. | 1 | 1 | ||||||||
| 10 | Emmanuel Nwachi | Heartland F.C. | 1 | 1 | ||||||||
| 10 | Wajdi Bouazzi | Espérance ST | 1 | 1 | ||||||||
| 10 | Walid Hichri | Espérance ST | 1 | 1 | ||||||||
| 10 | Mejdi Traoui | Espérance ST | 1 | 1 | ||||||||
| 10 | Wonder Sithole | Dynamos | 1 | 1 | ||||||||
| 10 | Thabani Kamusoko | Dynamos | 1 | 1 |
Players in bold are still competing in the competition