The knockout phase of the 2010–11 UEFA Champions League began on 15 February and concluded on 28 May 2011 with the final at Wembley Stadium in London, England. The knockout phase involved the 16 teams who finished in the top two in each of their groups in the group stage. Each tie in the knockout phase, apart from the final, is played over two legs, with each team playing one leg at home. The team that has the higher aggregate score over the two legs progresses to the next round. In the event that aggregate scores finish level, the away goals rule is applied, i.e. the team that scored more goals away from home over the two legs progresses. If away goals are also equal, then 30 minutes of extra time are played, divided into two 15-minute halves. The away goals rule is again applied after extra time, i.e. if there are goals scored during extra time and the aggregate score is still level, the visiting team qualifies by virtue of more away goals scored. If no goals are scored during extra time, the tie is decided by penalty shoot-out. In the final, the tie is played as a single match. If scores are level at the end of normal time in the final, extra time is played, followed by penalties if scores remain tied. In the draw for the round of 16, each of the eight group winners was drawn against a second-place team, with the group winners hosting the second leg. Teams from the same group or the same association were not allowed to be drawn against each other. There is a single draw after the round of 16 that determines the pairings for all subsequent rounds. For this draw, there are no seedings, and teams from the same group or the same association may be drawn with each other. Times are CET/CEST, as listed by UEFA.
The draw for the competition's round of 16 was held on 17 December 2010. The first legs of the round of 16 were played on 15, 16, 22 and 23 February, and the second legs were played on 8, 9, 15 and 16 March 2011.
First leg
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Second leg
Shakhtar Donetsk won 6–2 on aggregate. ---- Barcelona won 4–3 on aggregate. ---- Tottenham Hotspur won 1–0 on aggregate. ---- Schalke 04 won 4–2 on aggregate. ---- Manchester United won 2–1 on aggregate. ---- 3–3 on aggregate. Internazionale won on away goals. ---- Chelsea won 2–0 on aggregate. ---- Real Madrid won 4–1 on aggregate.''
Quarter-finals
The draw for the three remaining rounds was held on 18 March 2011 at UEFA's headquarters in Nyon. There were no seedings in the draw and teams from the same country could now be paired together in play. The first legs of the four quarter-final matches were played on 5 and 6 April, and the second legs were played on 12 and 13 April 2011.
First leg
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Second leg
Barcelona won 6–1 on aggregate. ---- Manchester United won 3–1 on aggregate. ---- Schalke 04 won 7–3 on aggregate. ---- Real Madrid won 5–0 on aggregate.
Semi-finals
The first legs were played on 26 and 27 April, and the second legs were played on 3 and 4 May 2011.
First leg
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Second leg
Barcelona won 3–1 on aggregate. ---- Manchester United won 6–1 on aggregate.
Tottenham Hotspur
Internazionale
Schalke 04
Lyon
Valencia
Copenhagen
Shakhtar Donetsk