2-Aminoethoxydiphenyl borate
2-Aminoethoxydiphenyl borate is a chemical that acts to inhibit both IP3 receptors and TRP channels. In research it is used to manipulate intracellular release of calcium ions and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.
