1999–2000 Alpha Ethniki
The 1999–2000 Alpha Ethniki was the 64th season of the highest football league of Greece. The season began on 19 September 1999 and ended on 28 May 2000. Olympiacos won their fourth consecutive and 29th Greek title.
Teams
Stadia and personnel
| Team | Manager1 | Location | Stadium | Capacity |
| AEK Athens |  Giannis Pathiakakis | Athens | Nikos Goumas Stadium | 27,729 |
| Apollon Smyrnis | Andreas Michalopoulos | Athens | Rizoupoli Stadium | 14,856 |
| Aris | Giannis Michalitsios | Thessaloniki | Kleanthis Vikelidis Stadium | 23,220 |
| Ethnikos Asteras | Spyros Livathinos | Athens | Michalis Kritikopoulos Stadium | 4,851 |
| Ionikos |  Oleg Blokhin | Piraeus | Neapoli Stadium | 4,999 |
| Iraklis | Angelos Anastasiadis | Thessaloniki | Kaftanzoglio Stadium | 27,770 |
| Kalamata | Vasilis Georgopoulos | Kalamata | Kalamata Municipal Stadium | 5,613 |
| Kavala | Georgios Paraschos | Kavala | Kavala National Stadium | 12,500 |
| OFI |  Eugène Gerards | Heraklion | Theodoros Vardinogiannis Stadium | 9,000 |
| Olympiacos | Giannis Matzourakis | Piraeus | Athens Olympic Stadium | 71,030 |
| Panachaiki | Christos Archontidis | Patras | Kostas Davourlis Stadium | 11,321 |
| Panathinaikos | Ioannis Kyrastas | Athens | Athens Olympic Stadium | 71,030 |
| Paniliakos | Arie Haan | Pyrgos | Pyrgos Stadium | 6,750 |
| Panionios | Christos Emvoliadis | Nea Smyrni | Nea Smyrni Stadium | 11,756 |
| PAOK |  Dušan Bajević | Thessaloniki | Toumba Stadium | 28,803 |
| Proodeftiki | Soulis Papadopoulos | Piraeus | Nikaia Municipal Stadium | 5,000 |
| Skoda Xanthi | Nikos Karageorgiou | Xanthi | Xanthi Ground | 9,500 |
| Trikala |  Zoran Babović | Trikala | Trikala Municipal Stadium | 15,000 |
Results
UEFA Cup Places
AEK qualified through the Cup, the 3rd league UEFA Cup place is decided between the teams within 5 points from 6th to 8th place.UEFA Cup Playoff
Iraklis with two Home-matches, Aris one, Panionios none