1980 Major League Baseball draft
First round selections
The following are the first round picks in the 1980 Major League Baseball draft.| Pick | Player | Team | Position | Hometown/School |
| 1 | Darryl Strawberry | New York Mets | Outfield | Crenshaw High School |
| 2 | Garry Harris | Toronto Blue Jays | Shortstop | Hoover High School |
| 3 | Ken Dayley | Atlanta Braves | Pitcher | University of Portland |
| 4 | Mike King | Oakland Athletics | Pitcher | Morningside College |
| 5 | Jeff Pyburn | San Diego Padres | Outfield | University of Georgia |
| 6 | Darnell Coles | Seattle Mariners | Shortstop | Eisenhower High School |
| 7 | Jessie Reid | San Francisco Giants | First Base | Lynwood High School |
| 8 | Cecil Espy | Chicago White Sox | Outfield | Point Loma High School |
| 9 | Ross Jones | Los Angeles Dodgers | Shortstop | Miami Hurricanes |
| 10 | Kelly Gruber | Cleveland Indians | Shortstop | Westlake High School |
| 11 | Don Schulze | Chicago Cubs | Pitcher | Lake Park High School |
| 12 | Jeff Reed | Minnesota Twins | Catcher | Joliet West High School |
| 13 | Henry Powell | Philadelphia Phillies | Catcher | Pine Forest High School |
| 14 | Tim Maki | Texas Rangers | Pitcher | Carrol High School |
| 15 | Don Collins | St. Louis Cardinals | Pitcher | Ferguson High School |
| 16 | Frank Wills | Kansas City Royals | Pitcher | Tulane University |
| 17 | Dennis Rasmussen | California Angels | Pitcher | Creighton University |
| 18 | Glenn Wilson | Detroit Tigers | Third Baseman | Sam Houston State University |
| 19 | Ron Robinson | Cincinnati Reds | Pitcher | Woodlake High School |
| 20 | Rich Renteria | Pittsburgh Pirates | Shortstop | South Gate High School |
| 21 | Jim Acker | Atlanta Braves | Pitcher | Texas Longhorns |
| 22 | Terry Francona | Montreal Expos | Outfield | University of Arizona |
| 23 | Billy Beane | New York Mets | Outfield | Mount Carmel High School |
| 24 | John Gibbons | New York Mets | Catcher | MacArthur High School |
| 25 | Dion James | Milwaukee Brewers | Outfield | McClatchy High School |
| 26 | Jeff Williams | Baltimore Orioles | Outfield | Princeton High School |
Compensation Picks
Other notable players
- Tim Teufel, 2nd round, 38th overall Minnesota Twins
- Dan Plesac, 2nd round, 41st overall St. Louis Cardinals
- Dave Miley, 2nd round, 47th overall Cincinnati Reds
- Tim Burke†, 2nd round, 49th overall Pittsburgh Pirates
- Joe Hesketh, 2nd round, 50th overall Montreal Expos
- Danny Tartabull†, 3rd round, 71st overall Cincinnati Reds
- Doug Drabek†, 4th round, 87th overall Cleveland Indians
- Ricky Horton, 4th round, 92nd overall St. Louis Cardinals
- Joe Orsulak, 6th round, 152nd overall Pittsburgh Pirates
- Randy Ready, 6th round, 154th overall Milwaukee Brewers
- Don Slaught, 7th round, 171st overall Kansas City Royals
- Lloyd McClendon, 8th round, 183rd overall New York Mets
- Eric Davis†, 8th round, 201st overall Cincinnati Reds
- John Farrell, 9th round, 212th overall Oakland Athletics
- Craig Lefferts, 9th round, 219th overall Chicago Cubs
- Dave Magadan, 12th round, 310th overall Boston Red Sox
- Ed Vande Berg, 13th round, 318th overall Seattle Mariners
- Terry Steinbach†, 16th round, 400th overall Cleveland Indians
- Jim Eisenreich, 16th round, 402nd overall Minnesota Twins
- Oil Can Boyd, 16th round, 414th overall Boston Red Sox
- Danny Jackson†, 24th round, 599th overall Oakland Athletics
- Darren Daulton†, 25th round, 629th overall Philadelphia Phillies
- Chris Sabo†, 30th round, 727th overall Montreal Expos
- Walt Terrell, 33rd round, 763rd overall Texas Rangers
- Rick Aguilera, 37th round, 803rd overall St. Louis Cardinals
‡ Hall of Famer
Football players drafted
- Turner Gill, 2nd round, 36th overall by the Chicago White Sox
- Kevin House, 19th round, 475th overall by the Chicago White Sox