1980–81 Mexican Primera División season
Statistics of Primera División de México for the 1980–81 season.
Overview
It was contested by 20 teams, and UNAM won the championship.Atletas Campesinos was promoted from Segunda División.
Unión de Curtidores was relegated to Segunda División.
Teams
| Team | City | Stadium | - |
| América | Mexico City | Azteca | - |
| Atlante | Mexico City | Azteca | - |
| Atlas | Guadalajara, Jalisco | Jalisco | - |
| Atletas Campesinos | Querétaro, Querétaro | Municipal de Querétaro | - |
| Atlético Español | Mexico City | Azteca | - |
| Atlético Potosino | San Luis Potosí, S.L.P. | Plan de San Luis | - |
| Cruz Azul | Mexico City | Azteca | - |
| Guadalajara | Guadalajara, Jalisco | Jalisco | - |
| León | León, Guanajuato | León | - |
| Monterrey | Monterrey, Nuevo León | Tecnológico | - |
| Neza | Nezahualcóyotl, State of Mexico | Municipal de Texcoco | - |
| Puebla | Puebla, Puebla | Cuauhtémoc | - |
| Tampico | Tampico, Tamaulipas | Tamaulipas | - |
| Tecos | Zapopan, Jalisco | Tres de Marzo | - |
| Toluca | Toluca, State of Mexico | Toluca 70 | - |
| Unión de Curtidores | León, Guanajuato | La Martinica | - |
| UANL | Monterrey, Nuevo León | Universitario | - |
| UdeG | Guadalajara, Jalisco | Jalisco | - |
| UNAM | Mexico City | Olímpico Universitario | - |
| Zacatepec | Zacatepec, Morelos | Agustín Coruco Díaz |
Group stage
Group 1
Group 2
Group 3
Group 4
Results
Relegation Playoff
Atlas won 2-3 on aggregate. Unión de Curtidores was relegated to Segunda División.Playoff
Semifinal
Group 1
Group 2
Final
UNAM won 4-2 on aggregate.----