1980–81 Alpha Ethniki
The 1980–81 Alpha Ethniki was the 45th season of the highest football league of Greece. The season began on 7 September 1980 and ended on 14 June 1981. Olympiacos won their second consecutive and 22nd Greek title.Results
Top goalscorers
| Rank | Player | Club | Goals |
| 1 |  Dinos Kouis | Aris | 21 |
| 2 | Grigoris Charalambidis | Doxa Drama | 15 |
| 3 | Thomas Liolios | Kastoria | 13 |
| 4 | Giannis Dintsikos | Kastoria | 12 |
| 4 |  Dušan Bajević | AEK Athens | 12 |
| 4 | Kostas Charalambidis | Larissa | 12 |
| 7 | Takis Papadimitriou | Panionios | 11 |
| 7 | Giorgos Togias | Korinthos | 11 |
| 9 | Giorgos Ananiadis | PAS Giannina | 10 |
| 9 | Maik Galakos | Olympiacos | 10 |
| 9 | Spyros Livathinos | Panionios | 10 |
| 9 | Dimitris Seitaridis | Ethnikos Piraeus | 10 |
