The 1972 election campaign dealt with a combination of Vietnam and domestic policy issues, and the role of the federal government in resolving these issues. The Coalition of the Liberal and Country parties had been in government for 23 years. Successive Coalition governments promoted conservative economics, trade, and defence. However, Australian economic prosperity during the post-war period of the 1950s and 1960s led to the emergence of a range of "quality of life" issues regarding urban development, education, and healthcare. By 1972 these "quality of life" issues came to represent a major political problem for the coalition parties. Traditionally all of these areas had been handled by the state governments, and the Coalition had always asserted the importance of states rights, a view backed by Liberal state premiers like Robert Askin and Henry Bolte. Between 1966 and 1972, Labor leader Gough Whitlam developed policies designed to deal with the problems of urban and regional development using the financial powers granted to the federal government under the Australian Constitution. As Whitlam put it, Labor focused on "cities, schools and hospitals", and these issues were electorally appealing especially to the young and growing baby boomer generation living in the outer suburbs of the major cities. By contrast, Coalition policies of conservative economic management, increasing trade, and Australian involvement in the Vietnam War disengaged a significant number of Australian voters. Australian involvement in the Vietnam War was initially popular. However, protests grew as the consequences of the war became apparent and the likelihood of a US-led victory diminished. A major part of the protests were directed at conscripting Australians to fight in the war. Liberal policies on Vietnam focused on the need to contain the spread of communism, but the gradual US and Australian troop withdrawal undermined this position. In 1971, Opposition Leader Gough Whitlam visited China. The Coalition heavily criticised the visit. The criticism soon became an embarrassment when US President Richard Nixon announced he would visit China the following year. Finally, the incumbent Prime Minister William McMahon was no match for Whitlam, a witty and powerful orator. McMahon's position was precarious to begin with, for he had only emerged as Liberal Leader after a prolonged period of turmoil following the Coalition's unexpectedly poor showing at the half-Senate election held in 1970, and various state elections. In early 1971, Country Party leader John McEwen had retired, to be replaced by Doug Anthony. McEwen, who had disliked McMahon, held a virtual veto over the possibility of his becoming Liberal leader, which he had exercised in 1968. Anthony declared that this veto was no longer in operation, clearing the way for a leadership challenge by McMahon against Prime Minister John Gorton. Gorton survived, but only narrowly, and soon called another leadership election, which he lost. This gave the impression of the Coalition being weak and divided, and consumed in internal struggles. McMahon was further weakened by concerns about inflation and negative press coverage. For example, Rupert Murdoch and his newspaper The Australian supported the ALP. The ALP ran a strong campaign under the famous slogan It's Time – a slogan which, coupled with its progressive policy programme, gave it great momentum within the electorate after 23 years of Conservative rule.
A special Senate election was held in Queensland to replace Liberal senator Annabelle Rankin, who resigned in 1971. Neville Bonner, who had been appointed to fill the casual vacancy by the Queensland Parliament, won the Senate position – the first Indigenous Australian elected to parliament. The election was held at the time of the House of Representatives elections as per Section 15 of the Constitution. Otherwise, no Senate election was held. As of 2020, this is the last Australian federal election that did not have a concurrent half or full Senate election.
The 1972 election ended 23 years of Liberal-Country rule—the longest unbroken run in government in Australian history. It is also unusual as Whitlam only scraped into office with a thin majority of 9 seats. Typically, elections that produce a change of government in Australia take the form of landslides. The comparatively small size of Whitlam's win is partly explained by his strong performance at the previous election of 1969, where he achieved a 7 percent swing, gaining 18 seats, from a low of 41 of 124 seats and a 43 percent two-party figure at the 1966 election. The new Labor Government of Gough Whitlam was eager to make long-planned reforms, although it struggled against a lack of experience in its cabinet and the onset of the 1973 oil crisis and 1973–75 recession. In addition, the Senate was hostile to Whitlam, with the Coalition and Democratic Labor Parties holding more seats than the ALP, as the term of the Senate at the time was 1971 to 1974. This in particular would make governing difficult and led to the early double dissolution election of 1974.