On September 29, 1956, Iowa defeated Indiana, 27–0, before a crowd of 25,000 at Memorial Stadium in Bloomington, Indiana, for the first conference game of the 1956 season. Iowa scored two touchdowns in the first quarter off an Indiana fumble and an interception. Iowa rushed for 242 yards to 76 yards for Indiana. On October 6, Notre Dame defeated Indiana, 20–6, before a crowd of 58,372 at Notre Dame Stadium in South Bend, Indiana. On October 13, Michigan State defeated Indiana, 53–6, before a crowd of 58,858 at Macklin Stadium in East Lansing, Michigan. The Spartans gained 264 rushing yards and 204 passing yards. Clarence Peaks also returned a punt 63 yards for a touchdown. Michigan State played backups for much of the second half with a total of 50 Spartans seeing game action. The outcome was Indiana's worst defeat since 1948. On October 20, Indiana defeated Nebraska, 19–14, before a crowd of 38,000 at Memorial Stadium in Lincoln, Nebraska. Nebraska led, 14–0, at halftime, but Indiana rallied for two touchdowns in the fourth quarter. The result was Indiana's first win of the season. Brad Bomba caught six passes in the game. On October 27, Indiana defeated Northwestern, 19–13, before a homecoming crowd of 23,000 at Memorial Stadium in Bloomington. The game was tied, 13–13, at halftime. Indiana intercepted a Northwestern pass with four minutes remaining to set up the winning touchdown. On November 3, Indiana defeated Marquette, 19–13, before a crowd of approximately 21,000 at Memorial Stadium in Bloomington. In the fourth quarter, Indiana's Arnold Steeves recovered a fumble at Marquette's 43-yard line to set up the winning touchdown. On November 10, Ohio State defeated Indiana, 35–14, before a crowd of 82,073 at Ohio Stadium in Columbus. The victory was Ohio State's 17th in a row against conference opponents, setting a new conference record. The Buckeyes also broke the Big Ten single-game record with 465 rushing yards against the Hoosiers. On November 17, Michigan defeated Indiana, 49–26, before a crowd of 58,515 at Michigan Stadium in Ann Arbor. Michigan led, 35–0, at halftime and gained for 427 yards in the game. Michigan's Terry Barr scored three touchdowns in the game. On November 24, in the annual battle for the Old Oaken Bucket, Purdue defeated Indiana, 39–20, at Ross–Ade Stadium in Lafayette, Indiana. In his final college game, Purdue quarterback Len Dawson threw two touchdown passes, both caught by end Lamar Lundy. Mel Dillard rushed for 130 yards and three touchdowns in the game and a conference high 873 yards for the season. The game proved to be a battle for last place in the conference, with Purdue finishing in ninth place and Indiana in tenth and last place.