11β-Hydroxyprogesterone


11β-Hydroxyprogesterone, also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone. It is a potent mineralocorticoid. Increased levels of 11β-OHP occur in 21-hydroxylase deficiency.
Along with its epimer 11α-hydroxyprogesterone, 11β-OHP has been identified as a very potent competitive inhibitor of both isoforms of 11β-hydroxysteroid dehydrogenase.